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The Immunological Genome Project: networks of gene expression in immune cells

Tracy S P Heng
Michio W Painter
Joonsoo Kang
Comments & Opinion01 Oct 2008
Nature Immunology

Volume: 9, P: 1091-1094
Molecular definition of the identity and activation of natural killer cells

Lanier and colleagues systematically define the transcriptome of mouse natural killer cells in several contexts, including activation states and relative to all other lymphocyte and myeloid populations profiled by the Immunological Genome Project consortium.

Natalie A Bezman
Charles C Kim
Christophe Benoist
Research19 Aug 2012
Nature Immunology

Volume: 13, P: 1000-1009
Transcriptional insights into the CD8⁺ T cell response to infection and memory T cell formation

Antigenic activation induces the generation of effector and memory CD8⁺ T cells. Goldrath and colleagues profile gene expression at various times after infection to identify transcriptional networks unique to each population.

J Adam Best
David A Blair
Christophe Benoist
Research10 Feb 2013
Nature Immunology

Volume: 14, P: 404-412
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

By comparing gene-expression profiles, Randolph and colleagues distinguish different types of macrophages and pinpoint the differences between macrophages and dendritic cells.

Emmanuel L Gautier
Tal Shay
Christophe Benoist
Research30 Sept 2012
Nature Immunology

Volume: 13, P: 1118-1128
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Using the Immunological Genome compendium, Brenner and colleagues shed light on the transcriptional programs that operate during the course of iNKT cell development and in peripheral CD4⁺ and CD4^– iNKT cell subsets.

Nadia R Cohen
Patrick J Brennan
Christophe Benoist
Research02 Dec 2012
Nature Immunology

Volume: 14, P: 90-99
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

The Immunological Genome Project aims to build a comprehensive database of gene-expression and gene-regulatory networks in the mouse immune system. Here Turley and colleagues analyze the transcriptomes of lymph-node stromal cells under steady-state and inflammatory conditions.

Deepali Malhotra
Anne L Fletcher
Christophe Benoist
Research01 Apr 2012
Nature Immunology

Volume: 13, P: 499-510

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The Immunological Genome Project: networks of gene expression in immune cells

Molecular definition of the identity and activation of natural killer cells

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

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Transcriptional insights into the CD8⁺ T cell response to infection and memory T cell formation