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Showing 1–5 of 5 results
Advanced filters: Author: Michiyo Sakuma Clear advanced filters

  • Spatiotemporal insight into photoactivation of the prototypical B12 photoreceptor CarH is revealed across nine orders of magnitude in time, identifying a transient adduct that distinguishes it from thermally activated B12 enzymes.

    • Ronald Rios-Santacruz
    • Harshwardhan Poddar
    • Giorgio Schirò
    Research
    Nature
    Volume: 650, P: 1045-1052

  • Crystal structures of cyanobacterial protochlorophyllide oxidoreductases reveal the basis of the photocatalytic activities of this enzyme, through the role of its active site in enabling the light-driven reduction of protochlorophyllide.

    • Shaowei Zhang
    • Derren J. Heyes
    • Nigel S. Scrutton
    Research
    Nature
    Volume: 574, P: 722-725

  • CarH is a bacterial B12-binding photoreceptor involved in transcriptional regulation. Here, the authors provide insights into B12 dynamics and associated cobalt redox changes following light activation. These demonstrate the CarH response integrates light and oxygen sensing.

    • Harshwardhan Poddar
    • Ronald Rios-Santacruz
    • David Leys
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Photoreceptor proteins utilise biological chromophores to regulate a large range of cellular processes in response to light. Here the authors identify and characterise a sub-family of multi-centre photoreceptors, termed photocobilins, that not only utilise B12 but also contain biliverdin (BV) as an additional chromophore.

    • Shaowei Zhang
    • Laura N. Jeffreys
    • Nigel S. Scrutton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Kynurenine 3-monooxygenase (KMO) regulates levels of neuroactive kynurenine pathway metabolites associated with neurodegeneration. Its inhibition ameliorates disease phenotypes in animal models but current inhibitors are not brain permeable. Through structure-based virtual screening and compound synthesis, Zhang et al. now develop KMO inhibitors that can enter the rodent brain to modulate metabolism in this pathway.

    • Shaowei Zhang
    • Michiyo Sakuma
    • Nigel S. Scrutton
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10