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npj Aging (2)
Nature Aging (2)

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Showing 1–4 of 4 results

Advanced filters: Author: Miguel Calvo-Rubio Clear advanced filters

A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan

Ortega-Molina et al. demonstrate that mouse models with mild, genetic overactivation of mTOR signaling develop chronic myeloid inflammation, causing reduced healthspan and lifespan, without an increase in tumor incidence.

Ana Ortega-Molina
Cristina Lebrero-Fernández
Alejo Efeyan
ResearchOpen Access07 Jun 2024
Nature Aging

Volume: 4, P: 1102-1120
The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

Anerillas et al. provide a strategy to eliminate senescent cells that leverages on their secretory needs. Inhibiting YAP–TEAD triggers endoplasmic reticulum stress that eliminates senescent cells from several tissues, improving age-related fibrosis.

Carlos Anerillas
Krystyna Mazan-Mamczarz
Myriam Gorospe
Research04 Sept 2023
Nature Aging

Volume: 3, P: 1237-1250
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

Miguel A. Aon
Sonia Cortassa
Steven J. Sollott
ResearchOpen Access04 Jan 2021
npj Aging and Mechanisms of Disease

Volume: 7, P: 1-16
Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

Michel Bernier
Ignacio Navas Enamorado
Rafael de Cabo
ResearchOpen Access27 Jun 2022
npj Aging

Volume: 8, P: 1-18