The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, the authors show that the release of mt-dsRNA to the cytosol is a general feature of senescent cells and a critical driver of their inflammatory secretome, known as senescence-associated secretory phenotype (SASP).
- Vanessa López-Polo
- Mate Maus
- Manuel Serrano
