Dib, Koneva et al. generate an scRNA-seq atlas of immune cells from human carotid endarterectomies and report the presence of a subset of pathogenic pro-inflammatory PLIN2hi/TREM1hi, derived from TREM2hi lipid-associated macrophages via TLR signaling, which correlates with an increased risk of cerebrovascular events.
- Lea Dib
- Lada A. Koneva
- Claudia Monaco