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Showing 1–9 of 9 results
Advanced filters: Author: Mihaela Pavlicev Clear advanced filters

  • Single-cell transcriptomes from the fetal–maternal interface of six species of mammals reveal a conserved gene expression signature of invasive trophoblast, stepwise evolution of decidual stromal cell types and co-evolutionary patterns in cell–cell signalling.

    • Daniel J. Stadtmauer
    • Silvia Basanta
    • Günter P. Wagner
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1469-1486

  • A module is a linked group of phenotypic traits that depend on each other but are relatively independent of other modules. The insight that developmental mechanisms are modular is important for their evolution, making modularity a key concept in evo–devo and beyond.

    • Günter P. Wagner
    • Mihaela Pavlicev
    • James M. Cheverud
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 921-931

  • Authors show that a common SNP upregulates endometrial Wnt4 expression and proimplantation genes in mouse proestrus and estrus. They suggest that this increases uterine permissiveness to embryo invasion, while decreasing resistance to invasion in reproductive cancers and endometriosis.

    • Mihaela Pavličev
    • Caitlin E. McDonough-Goldstein
    • Louis Muglia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

    • Günter P. Wagner
    • Jane P. Kenney-Hunt
    • James M. Cheverud
    Research
    Nature
    Volume: 456, P: E4

  • As more genetic sequence data are generated, evolutionary biology questions about inheritance and phenotypes can be examined with sophisticated analyses. This paper examines pleiotropy, or multiple effects from one genetic mutation, on the skeletal characteristics of mice. It is concluded there is no 'cost of complexity' for higher organisms.

    • Günter P. Wagner
    • Jane P. Kenney-Hunt
    • James M. Cheverud
    Research
    Nature
    Volume: 452, P: 470-472

  • Mammals with invasive placentation are more vulnerable to malignancy. Here, the authors propose that the evolution of invasibility of stromal tissue affects both placental and cancer invasion and present in vitro evidence in human and bovine fibroblasts consistent with this hypothesis.

    • Kshitiz
    • Junaid Afzal
    • Günter P. Wagner
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 1743-1753

  • In this article, the authors review the current understanding of the molecular mechanisms underlying cell type identity and discuss how new phenotypic features of cell types evolve. They explain how evolutionary lineage differs from developmental lineage and highlight how an evolutionary view of cell type identity can facilitate research in comparative cell biology.

    • Detlev Arendt
    • Jacob M. Musser
    • Günter P. Wagner
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 744-757