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Showing 1–5 of 5 results
Advanced filters: Author: Mihir B. Doshi Clear advanced filters

  • Lee, Park et al. show that selenium has the ability to directly regulate the redox state of ubiquinone by donating electrons from hydrogen selenide via sulfide quinone oxidoreductase, thus preventing lipid peroxidation.

    • Namgyu Lee
    • Sung Jin Park
    • Dohoon Kim
    Research
    Nature Metabolism
    Volume: 6, P: 343-358

  • Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

    • Andrew L. Hong
    • Yuen-Yi Tseng
    • Jesse S. Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Cancer cells rely on selenium uptake and selenocysteine biosynthesis to avoid ferroptosis. However, this mechanism makes them dependent on SEPHS2, an enzyme in the selenocysteine biosynthesis pathway for the detoxification selenide that is produced during selenocysteine formation.

    • Anne E. Carlisle
    • Namgyu Lee
    • Dohoon Kim
    Research
    Nature Metabolism
    Volume: 2, P: 603-611