Nature Search

Author Correction: Clinical relevance of tumour-associated macrophages

Mikael J. Pittet
Olivier Michielin
Denis Migliorini
Amendments and Corrections06 Apr 2022
Nature Reviews Clinical Oncology

Volume: 19, P: 424
Myocardial infarction accelerates atherosclerosis

Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.

Partha Dutta
Gabriel Courties
Matthias Nahrendorf
Research27 Jun 2012
Nature

Volume: 487, P: 325-329
Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade.

Peng Liu
Liwei Zhao
Guido Kroemer
ResearchOpen Access02 Apr 2019
Nature Communications

Volume: 10, P: 1-17
Publisher Correction: The expanding landscape of inflammatory cells affecting cancer therapy

Ralph Weissleder
Mikael J. Pittet
Amendments and Corrections06 Apr 2020
Nature Biomedical Engineering

Volume: 4, P: 573
Unveiling the antitumor function of ID3 in liver macrophages

A landmark study reveals how Kupffer cells, resident macrophages of the liver, can promote antitumor immunity. Central to this function is ID3, a Kupffer cell lineage-determining factor. The findings provide new insights into cancer therapy.

Anne-Gaëlle Goubet
Mikaël J. Pittet
News & Views01 Mar 2024
Nature Immunology

Volume: 25, P: 394-395
Therapeutically reeducating macrophages to treat GBM

Glioblastoma multiforme (GBM) is the most common type of aggressive malignant brain cancer. The current lack of successful therapeutics means that this disease has a dismal prognosis. However, a new study in mice offers hope for patients with GBM by demonstrating the efficacy of a novel drug that targets GBM-associated macrophages (pages 1264–1272).

Christopher Garris
Mikael J Pittet
News & Views07 Oct 2013
Nature Medicine

Volume: 19, P: 1207-1208
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

Infection by coagulase-positive Staphylococcus aureus (S. aureus) is the most common cause of acute endocarditis, a destructive and progressive condition of heart valves. Here, Peter Panizzi and his colleagues have developed a targeted, noninvasive fluorescence or positron emission technology imaging strategy that uses an engineered analog of prothrombin that can detect S. aureus in vivo in the endocarditic vegetations that form as a result of bacterial colonization.

Peter Panizzi
Matthias Nahrendorf
Ralph Weissleder
Research21 Aug 2011
Nature Medicine

Volume: 17, P: 1142-1146
Deep profiling of gene expression across 18 human cancers

Using unsupervised deep learning to generate low-dimensional latent spaces for gene-expression data can unveil biological insight across cancers.

Wei Qiu
Ayse B. Dincer
Su-In Lee
Research17 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 333-355
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes

Live cells and tissues are imaged over long time periods using a fast, non-toxic click chemistry.

Jina Ko
Martin Wilkovitsch
Jonathan C. T. Carlson
Research02 Jun 2022
Nature Biotechnology

Volume: 40, P: 1654-1662
Dendritic cells direct circadian anti-tumour immune responses

Rhythmic trafficking of dendritic cells to the tumour draining lymph node governs a circadian response of tumour-antigen-specific CD8⁺ T cells that is dependent on the circadian expression of the co-stimulatory molecule CD80.

Chen Wang
Coline Barnoud
Christoph Scheiermann
ResearchOpen Access05 Dec 2022
Nature

Volume: 614, P: 136-143
A durable murine model of spleen transplantation with arterial and venous anastomoses

Jose-Luiz Figueiredo
Fernando Santa-Cruz
Clinton S. Robbins
ResearchOpen Access04 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Durable and controlled depletion of neutrophils in mice

Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new method that overcomes these limitations to have potentially wide applicability in experimental studies.

Gael Boivin
Julien Faget
Etienne Meylan
ResearchOpen Access02 Jun 2020
Nature Communications

Volume: 11, P: 1-9
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.

Michael F. Cuccarese
J. Matthew Dubach
Ralph Weissleder
ResearchOpen Access08 Feb 2017
Nature Communications

Volume: 8, P: 1-10
The role of myeloid cells in cancer therapies

This Review describes recent advances in our understanding of tumour-associated myeloid cells in tumour progression and responses to therapy, discussing possible avenues to manipulate these cells in the tumour microenvironment.

Camilla Engblom
Christina Pfirschke
Mikael J. Pittet
Reviews24 Jun 2016
Nature Reviews Cancer

Volume: 16, P: 447-462
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

β-Cyclodextrin nanoparticles carrying an antagonist of the toll-like receptors TLR7 and TLR8 drive the M1 phenotype in tumour-associated macrophages and improve immunotherapy response rates in tumour mouse models when used with checkpoint blockade.

Christopher B. Rodell
Sean P. Arlauckas
Ralph Weissleder
Research21 May 2018
Nature Biomedical Engineering

Volume: 2, P: 578-588
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Drug-loaded nanoparticles allow controlled release and enhanced delivery, yet understanding in vivobehavior has been difficult. Here, the authors develop a platinum prodrug coupled to a polymer platform, and use intravital imaging to show that the nanoparticle accumulates in macrophages, from the which drug redistributes to neighboring tumour cells.

Miles A. Miller
Yao-Rong Zheng
Ralph Weissleder
ResearchOpen Access27 Oct 2015
Nature Communications

Volume: 6, P: 1-13
Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Peng Liu
Liwei Zhao
Guido Kroemer
Amendments and CorrectionsOpen Access17 Apr 2019
Nature Communications

Volume: 10, P: 1
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Amendments and Corrections07 Mar 2019
Nature Medicine

Volume: 25, P: 701
Therapeutic siRNA silencing in inflammatory monocytes in mice

In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

Florian Leuschner
Partha Dutta
Matthias Nahrendorf
Research09 Oct 2011
Nature Biotechnology

Volume: 29, P: 1005-1010
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Anthracyclines can induce a type 1 interferon response in tumor cells that may predict clinical response to these drugs.

Antonella Sistigu
Takahiro Yamazaki
Laurence Zitvogel
Research26 Oct 2014
Nature Medicine

Volume: 20, P: 1301-1309
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Clinical relevance of tumour-associated macrophages

The interaction of tumour-associated macrophages (TAMs) with cancer and stromal cells in the tumour microenvironment enables and sustains most of the hallmarks of cancer. The authors of this Review examine the diversity of TAMs in various cancer indications, which is being revisited with the advent of single-cell technologies, and discuss the functional roles of different TAM states, the prognostic and predictive value of TAM-related signatures as well as approaches involving TAMs that are currently being or will soon be tested in clinical trials.

Mikael J. Pittet
Olivier Michielin
Denis Migliorini
Reviews30 Mar 2022
Nature Reviews Clinical Oncology

Volume: 19, P: 402-421
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles

Mikael J Pittet
Filip K Swirski
Ralph Weissleder
Protocols27 Jun 2006
Nature Protocols

Volume: 1, P: 73-79
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

In this Review, Hanahan et al. discuss how, in response to tumorigenesis, nearly all cell types in the tumour microenvironment can be programmed to mediate — as functionally distinct subtypes — immunosuppressive programmes that result in the inhibition of antitumour T cell activity and the evasion of immune destruction.

Douglas Hanahan
Olivier Michielin
Mikael J. Pittet
Reviews24 Oct 2024
Nature Reviews Cancer

Volume: 25, P: 41-58
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Imaging in the era of molecular oncology

Ralph Weissleder
Mikael J. Pittet
Reviews02 Apr 2008
Nature

Volume: 452, P: 580-589
The expanding landscape of inflammatory cells affecting cancer therapy

This Perspective outlines the current map and known functions of populations of tumour-infiltrating myeloid cells in cancer, and discusses their implications for cancer therapy and biological research.

Ralph Weissleder
Mikael J. Pittet
Reviews18 Mar 2020
Nature Biomedical Engineering

Volume: 4, P: 489-498
Understanding the tumor immune microenvironment (TIME) for effective therapy

The tumor immune microenvironment influences tumor progression and response to immunotherapy; its further characterization will improve therapeutic outcome.

Mikhail Binnewies
Edward W. Roberts
Matthew F. Krummel
Reviews23 Apr 2018
Nature Medicine

Volume: 24, P: 541-550
Imaging macrophages with nanoparticles

Alongside their beneficial effects within the innate immune system, macrophages can also play a detrimental role in some disease settings. This Review discusses the range of nanoparticles that are known to target macrophages and hence, are able to act as imaging agents in cancer, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes and other inflammatory conditions.

Ralph Weissleder
Matthias Nahrendorf
Mikael J. Pittet
Reviews23 Jan 2014
Nature Materials

Volume: 13, P: 125-138
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells

Kate L. Stokes
Virna Cortez-Retamozo
David M. Feldser
ResearchOpen Access01 Apr 2019
Oncogenesis

Volume: 8, P: 1-13
Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

CD98hc in macrophages attenuates the severity of colitis. This change in the macrophage development is associated with increased expression of apoptotic genes, suggesting that CD98hc maintains the gut homeostasis by ensuring the development of gut macrophages.

Philipp Wuggenig
Berna Kaya
Jan Hendrik Niess
ResearchOpen Access18 Mar 2020
Communications Biology

Volume: 3, P: 1-19

Search

Author Correction: Clinical relevance of tumour-associated macrophages

Myocardial infarction accelerates atherosclerosis

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Publisher Correction: The expanding landscape of inflammatory cells affecting cancer therapy

Unveiling the antitumor function of ID3 in liver macrophages

Therapeutically reeducating macrophages to treat GBM

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

Deep profiling of gene expression across 18 human cancers

Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes

Dendritic cells direct circadian anti-tumour immune responses

A durable murine model of spleen transplantation with arterial and venous anastomoses

Durable and controlled depletion of neutrophils in mice

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

The role of myeloid cells in cancer therapies

Microbial network disturbances in relapsing refractory Crohn’s disease

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Therapeutic siRNA silencing in inflammatory monocytes in mice

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Clinical relevance of tumour-associated macrophages

Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Imaging in the era of molecular oncology

The expanding landscape of inflammatory cells affecting cancer therapy

Understanding the tumor immune microenvironment (TIME) for effective therapy

Imaging macrophages with nanoparticles

Natural killer cells limit the clearance of senescent lung adenocarcinoma cells

Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

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