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Showing 1–6 of 6 results
Advanced filters: Author: Mikko Metsä-Ketelä Clear advanced filters

  • Biocatalysis of the chemotherapy drug, doxorubicin, relies on the cytochrome P450 DoxA, which is inefficient. Here, the authors ameliorated the biosynthetic limitations by identifying DoxA redox partners and DnrV, which prevents product inhibition, helping improve microbial production.

    • Arina Koroleva
    • Erika Artukka
    • Mikko Metsä-Ketelä
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.

    • Janne J. Mäkinen
    • Yeonoh Shin
    • Georgiy A. Belogurov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Angucyclines are a class of natural products that harbor unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone, however, the enzymes leading to C-ring cleavage remain poorly understood. Here, the authors use targeted gene deletion and complementation as well as metabolomics to study the function of putative oxygenases involved in lugdunomycin biosynthesis, and reveal their potential roles towards C-ring cleavage.

    • Somayah S. Elsayed
    • Helga U. van der Heul
    • Gilles P. van Wezel
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-16

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631