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Showing 1–6 of 6 results
Advanced filters: Author: Miles W. Mee Clear advanced filters

  • AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

    • Luke Lambourne
    • Anupama Yadav
    • Marc Vidal
    ResearchOpen Access
    Nature Communications
    P: 1-19

  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • A platform developed for rapid isolation of SARS-CoV-2 variants also facilitates the characterization of variant immune evasion and viral fitness. The platform enabled rapid detection of the Omicron variant in samples of the first cases in Australia.

    • Anupriya Aggarwal
    • Alberto Ospina Stella
    • Stuart G. Turville
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 896-908

  • A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

    • Katja Luck
    • Dae-Kyum Kim
    • Michael A. Calderwood
    Research
    Nature
    Volume: 580, P: 402-408