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Showing 1–6 of 6 results
Advanced filters: Author: Min-Dian Li Clear advanced filters

  • In this instalment of our Career Pathways series, Cholsoon Jang and Min-Dian Li share how curiosity from a very early age has driven their scientific journeys.

    • Cholsoon Jang
    • Min-Dian Li
    Reviews
    Nature Metabolism
    Volume: 7, P: 231-233

  • Post-translational modifications (PTMs) couple feed-fast cycles to circadian clocks. Here, the authors systematically profile daily rhythms of the proteome, 4 PTMs and lipidome in mouse livers under TRF, providing a comprehensive resource detailing rhythmic liver functions shaped by meal timing.

    • Rongfeng Huang
    • Jianghui Chen
    • Min-Dian Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.

    • Yunfan Yang
    • Minnie Fu
    • Xiaoyong Yang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an endogenous appetite-inducing cannabinoid.

    • Min-Dian Li
    • Nicholas B. Vera
    • Xiaoyong Yang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12