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Showing 1–3 of 3 results
Advanced filters: Author: Min-Soon Cho Clear advanced filters

  • Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

    • Monika Haemmerle
    • Morgan L. Taylor
    • Anil K. Sood
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The aberrant expression of microRNAs and of the enzymes that control their processing has been reported in tumours, but the mechanisms involved are not clear. It is now shown that TAp63, a member of the p53 family of tumour suppressors, suppresses tumorigeneis and metastasis by directly controlling the expression of Dicer (a microRNA-processing enzyme) and Dicer-regulated microRNAs.

    • Xiaohua Su
    • Deepavali Chakravarti
    • Elsa R. Flores
    Research
    Nature
    Volume: 467, P: 986-990