Nature Search

Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates

Experiments and computations show that the organization and dynamics of molecules within and at interfaces of biomolecular condensates are governed by differential interaction strengths leading to the classification of adsorbents versus scaffolds.

Nadia A. Erkamp
Mina Farag
Rohit V. Pappu
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Mixtures of prion-like low complexity domains (PLCDs) are found in condensates such as stress granules. In this work, the authors report how the interplay between homotypic and heterotypic interactions contributes to condensate formation by mixtures of PLCDs.

Mina Farag
Wade M. Borcherds
Rohit V. Pappu
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Reply to: The conformations of protein chains at the interface of biomolecular condensates

Gaurav Chauhan
Mina Farag
Rohit V. Pappu
ResearchOpen Access19 Nov 2024
Nature Communications

Volume: 15, P: 1-4
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates

The time-dependent viscoelastic moduli of biomolecular condensates are connected to the functions that the condensates influence in cells. Now sticker and spacer residues in proteins are shown to regulate condensate viscoelasticity and ageing dynamics.

Ibraheem Alshareedah
Wade M. Borcherds
Priya R. Banerjee
Research02 Jul 2024
Nature Physics

Volume: 20, P: 1482-1491
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains

The complex link between protein sequence and phase behaviour for a family of prion-like low-complexity domains (PLCDs) has now been revealed. The results have uncovered a set of rules—which are interpreted using a stickers-and-spacers model—that govern the sequence-encoded phase behaviour of such PLCDs and enable physicochemical rationalizations that are connected to the underlying sequence composition.

Anne Bremer
Mina Farag
Tanja Mittag
Research20 Dec 2021
Nature Chemistry

Volume: 14, P: 196-207
Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.

Tingting Wu
Matthew R. King
Matthew D. Lew
ResearchOpen Access14 Mar 2025
Nature Physics

Volume: 21, P: 778-786
Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

The authors provide a physical description for condensates as complex fluids defined by small-world network structures for their interiors, and of interfaces featuring a preference of locally and globally expanded conformations.

Mina Farag
Samuel R. Cohen
Rohit V. Pappu
ResearchOpen Access13 Dec 2022
Nature Communications

Volume: 13, P: 1-15
Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats

Mina Y. George
Nermeen Farag
Iriny M. Ayoub
ResearchOpen Access14 May 2025
Scientific Reports

Volume: 15, P: 1-21
Programmable synthetic biomolecular condensates for cellular control

Dai et al. present a streamlined approach for the design and engineering of synthetic biomolecular condensates for controlling different cellular processes, such as gene flow, transcriptional regulation and modulation of protein circuits.

Yifan Dai
Mina Farag
Lingchong You
Research06 Feb 2023
Nature Chemical Biology

Volume: 19, P: 518-528
The reimplantation valve-sparing aortic root replacement technique for patients with Marfan syndrome: A single-center experience

Jamila Kremer
Mina Farag
Rawa Arif
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-8

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