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Showing 1–6 of 6 results
Advanced filters: Author: Ming-Ru Wu Clear advanced filters

  • A label-free, DNA-based proximity ligation assay that uses ligatable staple pairs enables the longitudinal quantification of DNA origami structural stability dynamics in vivo, with single-helix resolution for both wireframe and lattice designs.

    • Yang Wang
    • Iris Rocamonde-Lago
    • Björn Högberg
    ResearchOpen Access
    Nature Nanotechnology
    P: 1-9

  • Synthetic promoters can be superior to native ones but the design is challenging without knowledge of gene regulation. Here the authors develop a pipeline that allows for screening a synthetic promoter library to identify high performance promoters in potentially any given cell state of interest.

    • Ming-Ru Wu
    • Lior Nissim
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.

    • William C. W. Chen
    • Leonid Gaidukov
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • In this Progress article, Wu, Jusiak and Lu discuss how synthetic biology-based design principles can be applied to living cells to overcome key challenges in current cancer therapy and generate more robust, specific and effective gene circuit therapies.

    • Ming-Ru Wu
    • Barbara Jusiak
    • Timothy K. Lu
    Reviews
    Nature Reviews Cancer
    Volume: 19, P: 187-195

  • The ability to combine the production of multiple biologics into a single ‘on demand’ system could help in situations where resources are limited. Here the authors demonstrate a proof-of-concept approach for the co-production of three biologics, allowing singular, mixed and combination drug products.

    • Jicong Cao
    • Pablo Perez-Pinera
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13