Nature Search

Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Here, authors present cryo-EM structures and simulations of urea transporter members in resting-, transport-, or inactive-states bound with synthetic competitive, uncompetitive or noncompetitive inhibitor.

Shen-Ming Huang
Zhi-Zhen Huang
Jin-Peng Sun
ResearchOpen Access26 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Ganoderma tsuage promotes pain sensitivity in aging mice

Kai-Ning Yang
Chia-Ying Lin
Chia-Yi Tseng
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-8
Dimerization and antidepressant recognition at noradrenaline transporter

Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.

Heng Zhang
Yu-Ling Yin
Yi Jiang
Research15 May 2024
Nature

Volume: 630, P: 247-254
Structure of GPR101–Gs enables identification of ligands with rejuvenating potential

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

Zhao Yang
Jun-Yan Wang
Jin-Peng Sun
Research09 Nov 2023
Nature Chemical Biology

Volume: 20, P: 484-492
Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

Wen-Zhao Zhong
Hong-Hong Yan
Yi-Long Wu
ResearchOpen Access24 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-8
The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM_2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings

Chia-Yi Tseng
Jia-Yu Yu
Ming-Wei Chao
ResearchOpen Access02 May 2019
Scientific Reports

Volume: 9, P: 1-10
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations

Age-related macular degeneration is a prominent cause of irreversible blindness among the elderly. Here Huang et al.identify a novel missense variant in UBE3D that sheds new light on the pathogenesis of the disease.

Lv-Zhen Huang
Ying-Jie Li
Xiao-Xin Li
Research15 Apr 2015
Nature Communications

Volume: 6, P: 1-6
UGT2B28 genomic variation is associated with hepatitis B e-antigen seroconversion in response to antiviral therapy

Kung-Hao Liang
Chih-Lang Lin
Chau-Ting Yeh
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Sensitive genotyping of mutations in the EGFR gene from NSCLC patients using PCR-GoldMag lateral flow device

Xian-Ying Li
Chao Zhang
Ya-Li Cui
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

Shih-Yen Chen
Chi-Neu Tsai
Cheng-Hsun Chiu
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-7
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Multi-targeting agonists at GIPR, GLP-1R or GCGR are pursued vigorously. Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

Fenghui Zhao
Qingtong Zhou
Ming-Wei Wang
ResearchOpen Access25 Feb 2022
Nature Communications

Volume: 13, P: 1-16
N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain

Ming-Wei Chao
Chie-Pein Chen
Chia-Yi Tseng
ResearchOpen Access31 Aug 2016
Scientific Reports

Volume: 6, P: 1-14
Author Correction: Ganoderma tsuage promotes pain sensitivity in aging mice

Kai-Ning Yang
Chia-Ying Lin
Chia‑Yi Tseng
Amendments and CorrectionsOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1
Anionic redox reaction in layered NaCr_2/3Ti_1/3S₂ through electron holes formation and dimerization of S–S

Anionic redox reactions are gaining interest as a means to optimize capacities of alkaline ion batteries. Here, the authors investigate various charge compensation mechanisms and report S–S dimerization and the formation of electron holes on sulfur in a model sulfide cathode.

Tian Wang
Guo-Xi Ren
Zheng-Wen Fu
ResearchOpen Access01 Oct 2019
Nature Communications

Volume: 10, P: 1-12
The Impact of Constipation on Growth in Children

Hsun-Chin Chao
Shih-Yen Chen
Cheng-Hsun Chiu
Research01 Sept 2008
Pediatric Research

Volume: 64, P: 308-311
Correction: Corrigendum: Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

Shih-Yen Chen
Chi-Neu Tsai
Cheng-Hsun Chiu
Amendments and CorrectionsOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice

Fu-wen Zuo
Zhi-yong Liu
Fan Yi
Research16 Jan 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1019-1031
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

Li-hua Zhao
Qing-ning Yuan
H. Eric Xu
Research08 Dec 2022
Acta Pharmacologica Sinica

Volume: 44, P: 1227-1237
A GALNT14 rs9679162 genotype-guided therapeutic strategy for advanced hepatocellular carcinoma: systemic or hepatic arterial infusion chemotherapy

Chen-Chun Lin
Chao-Wei Hsu
Chau-Ting Yeh
Research14 Oct 2019
The Pharmacogenomics Journal

Volume: 20, P: 57-68
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study

Tien-Jyun Chang
Wen-Chang Wang
I-Te Lee
ResearchOpen Access12 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Shyh-Yuh Wei
Hsiang-Tai Chao
Jen-Chuen Hsieh
ResearchOpen Access24 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

Shyh-Yuh Wei
Li-Fen Chen
Jen-Chuen Hsieh
ResearchOpen Access06 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

Gravitational wave astronomy has opened the door to test general relativity and the effect of gravity in the Universe. The authors present the capabilities of an overlap between space gravitational wave detectors LISA and Taiji to constrain the Hubble constant to 0.5%, in 10 years, and what can be learned from the satellite pilot Taiji-1 launched in 2019.

Yue-Liang Wu
Zi-Ren Luo
Zi-Ming Zou
ReviewsOpen Access24 Feb 2021
Communications Physics

Volume: 4, P: 1-7

Search

Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Ganoderma tsuage promotes pain sensitivity in aging mice

Dimerization and antidepressant recognition at noradrenaline transporter

Structure of GPR101–Gs enables identification of ligands with rejuvenating potential

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM_2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings

Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations

UGT2B28 genomic variation is associated with hepatitis B e-antigen seroconversion in response to antiviral therapy

Sensitive genotyping of mutations in the EGFR gene from NSCLC patients using PCR-GoldMag lateral flow device

Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain

Author Correction: Ganoderma tsuage promotes pain sensitivity in aging mice

Anionic redox reaction in layered NaCr_2/3Ti_1/3S₂ through electron holes formation and dimerization of S–S

The Impact of Constipation on Growth in Children

Correction: Corrigendum: Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

A GALNT14 rs9679162 genotype-guided therapeutic strategy for advanced hepatocellular carcinoma: systemic or hepatic arterial infusion chemotherapy

Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study

The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

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