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Showing 1–4 of 4 results
Advanced filters: Author: Ming-liang Ji Clear advanced filters

  • Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus.

    • Ming-liang Ji
    • Hua Jiang
    • Jun Lu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.

    • Chun-Hua Liu
    • Zheng Gong
    • Jin-Peng Sun
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-coupled miR-141 into the NP alleviates IDD in mice.

    • Ming-liang Ji
    • Hua Jiang
    • Jun Lu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14