Nature Search

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects is of interest for managing gout progression. Here, the authors employ a dual-target pharmacophore model to design derivatives of β-carboline-1-propionic acid and identify a drug candidate demonstrating potent uric acid-lowering activity in male hyperuricemia mouse models and mitigating NLRP3-mediated inflammation.

Zhijiao Zhang
Xiaoyu Shi
Peng Zhan
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-13
A two-stream convolutional neural network for microRNA transcription start site feature integration and identification

Mingyu Cha
Hansi Zheng
Haiyan Hu
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
A novel evaluation benchmark for medical LLMs illuminating safety and effectiveness in clinical domains

Shirui Wang
Zhihui Tang
Jianxiong Wu
ResearchOpen Access26 Dec 2025
npj Digital Medicine

Volume: 9, P: 1-15
Observation of two-dimensional time-reversal broken non-Abelian topological states

Non-Abelian band topology reveals the global quantum geometry of multiple Bloch bands and unveils a new paradigm for topological physics. Here, authors find rich T-broken non-Abelian topological phases and their transitions with an unexpected connection to multigap antichiral edge states.

Yuze Hu
Mingyu Tong
Yihao Yang
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education

Yu et al. developed AIPatient, a virtual patient that uses a large language model-based AI in curating a medical knowledge base that holds realistic and personality-aware clinical conversations. The system shows high accuracy in answering questions and medical-term recognition, with readable, reliable, and consistent outputs for medical training.

Huizi Yu
Jiayan Zhou
Lizhou Fan
ResearchOpen Access19 Dec 2025
Communications Medicine

Volume: 6, P: 1-12
Author Correction: Observation of two-dimensional time-reversal broken non-Abelian topological states

Yuze Hu
Mingyu Tong
Yihao Yang
Amendments and CorrectionsOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1
Sub-1.4eV bandgap inorganic perovskite solar cells with long-term stability

Current research focus on the perovskites solar cells (PSCs) is mainly limited to the lead-based ones with bandgaps above 1.5 eV. Here Hu et al. report efficient and stable inorganic tin-containing PSCs, opening doors to exploring abundant perovskite materials with bandgaps lower than 1.4 eV.

Mingyu Hu
Min Chen
Yuanyuan Zhou
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-10
Radiomics signature on CECT as a predictive factor for invasiveness of lung adenocarcinoma manifesting as subcentimeter ground glass nodules

Wufei Chen
Ming Li
Hao Wu
ResearchOpen Access11 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production

Xing Li
Ling Zhou
Min Long
ResearchOpen Access27 Aug 2021
Experimental & Molecular Medicine

Volume: 53, P: 1238-1249
An artificial neural network-based radiomics model for predicting the radiotherapy response of advanced esophageal squamous cell carcinoma patients: a multicenter study

Yuchen Xie
Qiang Liu
Xiaozhi Zhang
ResearchOpen Access29 May 2023
Scientific Reports

Volume: 13, P: 1-10
Genomic identification and expression analysis of nuclear pore proteins in Malus domestica

Chenguang Zhang
Na An
Xiaolin Ren
ResearchOpen Access15 Oct 2020
Scientific Reports

Volume: 10, P: 1-15
Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China

Lei Yan
Dan Liu
Hai Xu
ResearchOpen Access17 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100

Search

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

A two-stream convolutional neural network for microRNA transcription start site feature integration and identification

A novel evaluation benchmark for medical LLMs illuminating safety and effectiveness in clinical domains

Observation of two-dimensional time-reversal broken non-Abelian topological states

Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education

Author Correction: Observation of two-dimensional time-reversal broken non-Abelian topological states

Sub-1.4eV bandgap inorganic perovskite solar cells with long-term stability

Radiomics signature on CECT as a predictive factor for invasiveness of lung adenocarcinoma manifesting as subcentimeter ground glass nodules

Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production

An artificial neural network-based radiomics model for predicting the radiotherapy response of advanced esophageal squamous cell carcinoma patients: a multicenter study

Genomic identification and expression analysis of nuclear pore proteins in Malus domestica

Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China

Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Search

Quick links

Search

Filter By:

Search

Quick links