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Showing 1–6 of 6 results
Advanced filters: Author: Mingzhou Ye Clear advanced filters

  • Nicotinamide adenine dinucleotide (NAD+) is an immune modulator that was suggested as a potential treatment for sepsis, but its in vivo benefits are contradictory and its low bioavailability as a free drug hampers potential clinical translation. Here the authors show that using a lipid-coated nanoparticle to deliver NAD+ to the cell cytosol can effectively replenish the intracellular content of NAD+ and reduce the extent of the inflammatory response in mouse models of sepsis.

    • Mingzhou Ye
    • Yi Zhao
    • Shaoqin Gong
    Research
    Nature Nanotechnology
    Volume: 17, P: 880-890

  • Antimicrobial resistance is becoming more prevalent. Here the authors use multimodal nanoparticles to modulate the infected microenvironment, recruit neutrophils and alleviate hypoxia to restore neutrophil function, demonstrating therapeutic efficacy against MRSA infections in mice.

    • Jingcheng Zhu
    • Ruosen Xie
    • Shaoqin Gong
    Research
    Nature Nanotechnology
    Volume: 19, P: 1032-1043

  • Epigenetic and genetic factors have a role in obesity but the role of epigenetics in this disease is unclear. Here, Liet al. investigated global DNA methylation patterns in three breeds of pigs that have different fat contents, providing a resource for the further analysis of differentially methylated gene promoters in obesity.

    • Mingzhou Li
    • Honglong Wu
    • Ruiqiang Li
    Research
    Nature Communications
    Volume: 3, P: 1-11

  • Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment following radiotherapy, showing improved anti-tumor immune responses in radiotherapy-treated tumors when combined with immune checkpoint inhibitors.

    • Ying Zhang
    • Raghava N. Sriramaneni
    • Zachary S. Morris
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

    • Fusheng Zhou
    • Hongzhi Cao
    • Xuejun Zhang
    Research
    Nature Genetics
    Volume: 48, P: 740-746