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Showing 1–11 of 11 results
Advanced filters: Author: Minnie M. Sarwal Clear advanced filters

  • Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, that repertoire diversity is positively associated with the incidence of kidney rejection.

    • Silvia Pineda
    • Tara K. Sigdel
    • Minnie M. Sarwal
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine.

    • Joshua Y. C. Yang
    • Minnie M. Sarwal
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 309-326

  • Using DNA microarray–derived gene expression data from complex tissues and the relative frequencies of cell types in the tissue as input the algorithm csSAM finds cell type–specific differentially expressed genes.

    • Shai S Shen-Orr
    • Robert Tibshirani
    • Atul J Butte
    Research
    Nature Methods
    Volume: 7, P: 287-289

  • Although long-term kidney allograft failure is broadly classified as T cell- or antibody-mediated, this dichotomy is not always apparent in all patients, highlighting the need for improved allograft tissue characterisation. Here, the authors use single-cell RNA sequencing and multiplex imaging for transcriptomic and spatial profiling of allograft tissue from patients experiencing different degrees of rejection severity.

    • Baptiste Lamarthée
    • Jasper Callemeyn
    • Maarten Naesens
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • The past few decades have seen great advances in genetics and molecular cell biology. Advances in chemistry and engineering have enabled increased data throughput, permitting the study of complete sets of molecules with increasing speed and accuracy using techniques such as genomics, transcriptomics, proteomics, and metabolomics. In this Review, the authors discuss the opportunities that molecular diagnostic tools have to offer both basic scientists and translational researchers in the field of transplantation.

    • Maarten Naesens
    • Minnie M. Sarwal
    Reviews
    Nature Reviews Nephrology
    Volume: 6, P: 614-628

  • Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often recurs after transplantation, and ~40 years ago, an unknown soluble factor in the recipient was hypothesized to exist to explain such cases. Jochen Reiser and his colleagues use data from human and mouse studies to show that soluble uPAR may be the long-sought-after soluble factor.

    • Changli Wei
    • Shafic El Hindi
    • Jochen Reiser
    Research
    Nature Medicine
    Volume: 17, P: 952-960

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594