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Showing 1–7 of 7 results
Advanced filters: Author: Minoti Apte Clear advanced filters

  • Research has highlighted the importance of the stroma in pancreatic cancer, in particular the role of complex interactions between cancer and stromal cells. A new study describes a novel mechanism by which stromal pathways can be modulated to inhibit tumour growth. The findings support the concept that a multipronged therapeutic approach targeting pancreatic cancer cells and cancer stroma could improve clinical outcomes for this disease.

    • Minoti V. Apte
    • Jeremy S. Wilson
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 385-387

  • The management of alcoholic pancreatitis is mostly reactive; little is done to prevent disease progression. It is time for physicians to pay attention to the root cause of the condition—that is, alcohol—rather than just responding to its effects. This article discusses an important paper that describes the first prospective, randomized, controlled, clinical trial to investigate the effect of brief interventions for alcohol abuse on the progression of alcoholic pancreatitis.

    • Minoti V. Apte
    • Romano C. Pirola
    • Jeremy S. Wilson
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 6, P: 321-322

  • Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the role of the tumour microenvironment and the microbiome in the development and progression of the disease, as well as on the promising potential of artificial intelligence for early diagnosis and outcome prediction.

    • Minoti Apte
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 96-97

  • In 2015, an estimated 367,000 new cases of pancreatic cancer were diagnosed worldwide; this disease is aggressive and patients face a dismal overall prognosis. In this Primer, the current understanding of pathophysiological, molecular, translational and clinical aspects of pancreatic cancer are described.

    • Jorg Kleeff
    • Murray Korc
    • John P. Neoptolemos
    Reviews
    Nature Reviews Disease Primers
    Volume: 2, P: 1-22