Through shallow single-cell sequencing of genomic DNA followed by clustering analysis, Velazquez-Villarreal et al. reveal sub-clones of the melanoma cell line COLO829 and further identify and validate chromosome translocations and copy number changes. This study illustrates how copy number variation analysis can provide insights into cancer cell heterogeneity.
- Enrique I. Velazquez-Villarreal
- Shamoni Maheshwari
- David W. Craig
