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Advanced filters: Author: Miranda L. Simes Clear advanced filters

  • Fragment screening and medicinal chemistry optimization led to development of a small-molecule inhibitor of RING1B–BMI1 E3 ligase, blocking the H2A ubiquitination activity of the Polycomb repressive complex 1 and inducing differentiation in leukemia cells.

    • Shirish Shukla
    • Weijiang Ying
    • Tomasz Cierpicki
    Research
    Nature Chemical Biology
    Volume: 17, P: 784-793