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Showing 1–3 of 3 results
Advanced filters: Author: Mircea Gabriel Stoleriu Clear advanced filters

  • Using multiplexed spatially resolved transcriptomic approaches, the authors generate a topographic atlas of the healthy adult lung with location-related gene expression variability or neighbourhood changes as exemplified by COPD patient sample analysis.

    • Alexandra B. Firsova
    • Sergio Marco Salas
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Lung fibrosis development involves alveolar macrophages, with mechanisms that are incompletely understood. Here, the authors show that alveolar macrophages mediate the disassembly of pleuro-alveolar junctions, driving fibrosis via connective tissue transfer, and demonstrate that targeting this process can reverse chronic fibrosis in mice.

    • Adrian Fischer
    • Wei Han
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18