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Showing 1–3 of 3 results

Advanced filters: Author: Miriam Lechner Clear advanced filters

Inhibitors supercharge kinase turnover through native proteolytic circuits

Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

Natalie S. Scholes
Martino Bertoni
Georg E. Winter
ResearchOpen Access26 Nov 2025
Nature

Volume: 649, P: 1032-1041
Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease

Marcel Tisch
Stefanie M. Geisler
Frank Edenhofer
ResearchOpen Access09 Jan 2026
Molecular Psychiatry

P: 1-14
Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly

The biogenesis of eukaryotic ribosomes involves the coordinated interplay of a large number of assembly factors. Here, the authors detail how the conserved KH domain-containing assembly factors Dim2 and Krr1 function in ordering key events during ribosome maturation.

Miriam Sturm
Jingdong Cheng
Ed Hurt
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-13