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Showing 1–2 of 2 results
Advanced filters: Author: Miriam Manook Clear advanced filters
  • Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.

    • Robin Schmitz
    • Zachary W. Fitch
    • Stuart J. Knechtle
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • Song et al. describe an immunoassay method, which is a multiplex, fluorescence-barcoded cell lines system that enables high-throughput screening of antibodies binding to large number of protein variants in a single-tube manner. They demonstrate the utility of this tool by assessing binding of different antibodies to a panel of influenza hemagglutinin antigens and to epitope/domain map CCR2 and CCR5 antibodies.

    • Shengli Song
    • Miriam Manook
    • Garnett Kelsoe
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9