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Showing 1–3 of 3 results
Advanced filters: Author: Mirjam Geibel Clear advanced filters

  • Glucocorticoid levels in the body are controlled by an intricate feedback system acting on the hypothalamus. Here the authors provide molecular insight into this process, identifying TrkB signalling in cholecystokinin-GABAergic neurons as a key component of hypothalamic glucocorticoid signalling.

    • Mirjam Geibel
    • Sylvia Badurek
    • Liliana Minichiello
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • The in-tissue architectures of β-amyloid and tau pathology in a postmortem Alzheimer’s disease donor brain are determined, showing fibril heterogeneity is spatially organized by subcellular location and suggesting applications to a broad range of neurodegenerative diseases.

    • Madeleine A. G. Gilbert
    • Nayab Fatima
    • René A. W. Frank
    ResearchOpen Access
    Nature
    Volume: 631, P: 913-919

  • The neurotrophic factor BDNF is implicated in striatal cell long-term survival. Besusso et al. selectively delete BDNF receptors in the striatal circuitry of mice and find that this leads to hyperlocomotion, which is associated with dopamine receptor-dependent increases in specific kinases.

    • Dario Besusso
    • Mirjam Geibel
    • Liliana Minichiello
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-12