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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Here the authors visualize SARS-CoV-2 infected cells by in situ cryo-electron tomography, delineating the structural organization and conformational changes that occur during virus replication and budding; and provide insight into vRNP architecture and RNA networks in double membrane vesicles.

Steffen Klein
Mirko Cortese
Petr Chlanda
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Phosphatidylserine-exposing extracellular vesicles in body fluids can inhibit infection of viruses that use viral apoptotic mimicry for infection, but not viruses that use other entry mechanisms.

Rüdiger Groß
Hanna Reßin
Janis A. Müller
ResearchOpen Access25 Mar 2024
Nature Microbiology

Volume: 9, P: 905-921
Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Cryo-electron microscopy and tomography studies reveal the structures, conformations and distributions of spike protein trimers on intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions and provide a basis for understanding the interactions of the spike protein with neutralizing antibodies.

Zunlong Ke
Joaquin Oton
John A. G. Briggs
Research17 Aug 2020
Nature

Volume: 588, P: 498-502
Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma

Ugo Chianese
Chiara Papulino
Rosaria Benedetti
ResearchOpen Access20 Jan 2026
Signal Transduction and Targeted Therapy

Volume: 11, P: 1-19
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Double membrane vesicles (DMV) are used as replication organelles by several RNA viruses. Applying proteomics and lipidomics, Tabata and Prasad et al. find that two cellular acyltransferases (AGPAT1/2), responsible for synthesis of phosphatidic acid, play a role in the DMV-biogenesis of HCV and SARS-CoV-2, highlighting a common biogenesis mechanism for evolutionary distant positive-strand RNA viruses.

Keisuke Tabata
Vibhu Prasad
Ralf Bartenschlager
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-15
ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Flavivirus infection leads to a rearrangement of host cell ER membranes that creates an environment permissive to viral replication. The morphology of these membrane rearrangements is known, but the mechanisms involved are unclear. Here, atlastins—ER-resident membrane-bound GTPases of the dynamin family—are shown to be targeted by flaviviruses to establish their replication organelle and for virion maturation and secretion.

Christopher J. Neufeldt
Mirko Cortese
Ralf Bartenschlager
Research21 Oct 2019
Nature Microbiology

Volume: 4, P: 2416-2429
Semen inhibits Zika virus infection of cells and tissues from the anogenital region

Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.

Janis A. Müller
Mirja Harms
Jan Münch
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-14
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees

Antonella Folgori
Stefania Capone
Alfredo Nicosia
Research05 Feb 2006
Nature Medicine

Volume: 12, P: 190-197
Rewiring cellular networks by members of the Flaviviridae family

In this Review, Bartenschlager and colleagues discuss howFlaviviridaeviruses rewire cellular pathways and co-opt organelles. They compare strategies employed by flaviviruses with those employed by hepaciviruses and discuss the importance of these virus–host interactions in the context of viral replication and antiviral therapies.

Christopher J. Neufeldt
Mirko Cortese
Ralf Bartenschlager
Reviews12 Feb 2018
Nature Reviews Microbiology

Volume: 16, P: 125-142
An orthogonal proteomic survey uncovers novel Zika virus host factors

Integrative analyses identify host proteins that are modulated by Zika virus at multiple levels and provide a comprehensive framework for the understanding of Zika virus-induced changes to cellular pathways.

Pietro Scaturro
Alexey Stukalov
Andreas Pichlmair
Research03 Sept 2018
Nature

Volume: 561, P: 253-257
Exploiting a chink in the armor: engineering broadly neutralizing monoclonal antibodies for SARS-like viruses

Mirko Cortese
Christopher J. Neufeldt
Research HighlightsOpen Access11 Jun 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-2
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by cGAS-STING and NF-κB signalling, which could provide a potential avenue for the development of future therapies against SARS-CoV-2.

Christopher J. Neufeldt
Berati Cerikan
Ralf Bartenschlager
ResearchOpen Access12 Jan 2022
Communications Biology

Volume: 5, P: 1-15
A portrait of the infected cell: how SARS-CoV-2 infection reshapes cellular processes and pathways

Valentina Marano
Štěpánka Vlachová
Mirko Cortese
ReviewsOpen Access17 Dec 2024
npj Viruses

Volume: 2, P: 1-9

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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Semen inhibits Zika virus infection of cells and tissues from the anogenital region

A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees

Rewiring cellular networks by members of the Flaviviridae family

An orthogonal proteomic survey uncovers novel Zika virus host factors

Exploiting a chink in the armor: engineering broadly neutralizing monoclonal antibodies for SARS-like viruses

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

A portrait of the infected cell: how SARS-CoV-2 infection reshapes cellular processes and pathways

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