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A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

Here the authors show that there are alterations in the glycome profile of serum IgG Fc regions that precede the diagnosis of Crohn’s disease by many years and are associated with complications during disease. This altered glycome triggers innate immune cell activation at a preclinical phase, which is the basis for the transition from healthy tissue to intestinal inflammation.

Joana Gaifem
Cláudia S. Rodrigues
Salomé S. Pinho
ResearchOpen Access30 Jul 2024
Nature Immunology

Volume: 25, P: 1692-1703
Profiling and genetic control of the murine immunoglobulin G glycome

Comprehensive glycome profiling of immunoglobulin G (IgG) in 95 strains of mice from the Collaborative Cross genetics resource reveals the extent and variability of IgG glycosylation in vivo.

Jasminka Krištić
Olga O. Zaytseva
Gordan Lauc
Research09 Apr 2018
Nature Chemical Biology

Volume: 14, P: 516-524
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene expression.

N. T. Ventham
N. A. Kennedy
J. Satsangi
ResearchOpen Access25 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Comparative analysis of transferrin and IgG N-glycosylation in two human populations

A large-scale comparative study in two human populations analyzes human plasma transferrin and immunoglobulin G (IgG) N-glycosylation profiles and their association with age, sex, and various biochemical and physiological traits.

Irena Trbojević-Akmačić
Frano Vučković
Gordan Lauc
ResearchOpen Access23 Mar 2023
Communications Biology

Volume: 6, P: 1-13
Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system

Gabriela Barrientos
Siniša Habazin
Melanie L. Conrad
ResearchOpen Access17 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery

Ivan Gudelj
Marco Baciarello
Massimo Allegri
ResearchOpen Access09 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Changes in IgG and total plasma protein glycomes in acute systemic inflammation

Mislav Novokmet
Edita Lukić
Gordan Lauc
ResearchOpen Access11 Mar 2014
Scientific Reports

Volume: 4, P: 1-10

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A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

Profiling and genetic control of the murine immunoglobulin G glycome

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Comparative analysis of transferrin and IgG N-glycosylation in two human populations

Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system

Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery

Changes in IgG and total plasma protein glycomes in acute systemic inflammation

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