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Showing 1–10 of 10 results
Advanced filters: Author: Mitchell E. Fane Clear advanced filters

  • Changes in the microenvironment of the aged lung relative to younger lung tissue can lead to the reactivation of dormant melanoma cells through a mechanism that involves a decrease in WNT5A and AXL signalling and an increase in MERTK.

    • Mitchell E. Fane
    • Yash Chhabra
    • Ashani T. Weeraratna
    Research
    Nature
    Volume: 606, P: 396-405

  • Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

    • Yogesh Goyal
    • Gianna T. Busch
    • Arjun Raj
    Research
    Nature
    Volume: 620, P: 651-659

  • Identifying memory and state switching in single cells remains elusive. Here, the authors develop a method, scMemorySeq, by combining cell barcoding and scRNA-seq and apply it to human melanoma cells to track lineages as they switch states between a drug-susceptible state and a state primed for drug resistance.

    • Guillaume Harmange
    • Raúl A. Reyes Hueros
    • Sydney M. Shaffer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • ClampFISH 2.0 enables highly specific multiplexed signal amplification in RNA FISH. The approach was used to detect 10 RNA species that ranged in abundance in more than 1 million cells and is also applicable to tissue sections.

    • Ian Dardani
    • Benjamin L. Emert
    • Arjun Raj
    Research
    Nature Methods
    Volume: 19, P: 1403-1410

  • A genetic screen designed to capture modulators of single-cell state variability identifies a new mode of altering resistance to BRAF inhibition in melanoma that pushes cells toward a more differentiated state. Modulating cellular plasticity may provide a new avenue to overcome drug resistance.

    • Eduardo A. Torre
    • Eri Arai
    • Arjun Raj
    Research
    Nature Genetics
    Volume: 53, P: 76-85

  • Rebecca and colleagues discuss the complex biology of metastatic melanoma, as well as determinants of resistance to therapy and existing and promising therapy strategies.

    • Bailey M. Robertson
    • Mitchell E. Fane
    • Vito W. Rebecca
    Reviews
    Nature Cancer
    Volume: 5, P: 964-982

  • The majority of cancers arise in individuals over the age of 60. This Review discusses how ageing tissues through changes in the extracellular matrix as well as in the functions of fibroblasts and immune cells can impact tumour initiation, progression and response to therapy.

    • Mitchell Fane
    • Ashani T. Weeraratna
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 89-106