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Showing 1–4 of 4 results
Advanced filters: Author: Mitsu Ikura Clear advanced filters

  • Despite well-established tumorigenic roles of KRAS mutants, targeting their smooth surfaces was a challenge, which was overcome through the development of G12C-specific covalent inhibitors. A new study shows that optimizing non-covalent interactions with a cryptic pocket produces remarkable potency for another hotspot mutation.

    • Christopher B. Marshall
    • Mitsuhiko Ikura
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 578-579

  • SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation, thus Q61H pancreatic cancer cells maintain MAPK signalling and are refractory to SHP2 inhibitors.

    • Teklab Gebregiworgis
    • Yoshihito Kano
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.

    • Noboru Ishiyama
    • Ritu Sarpal
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.

    • Marc Fahrner
    • Michael Stadlbauer
    • Christoph Romanin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12