Further understanding of the molecular mechanisms underlying the pathogenesis of diabetic nephropathy is necessary for the improved management of the disease. In this Review, the authors discuss the emerging evidence that suggests a key role for epigenetic mechanisms and noncoding RNAs in the pathogenesis of diabetic nephropathy and metabolic memory—the phenomenon of prolonged benefits of good blood glucose control.
- Mitsuo Kato
- Rama Natarajan
