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Showing 1–8 of 8 results
Advanced filters: Author: Mohamad Navab Clear advanced filters

  • Not only the levels, but also the function and components of HDL-cholesterol appear to play a role in atherosclerosis. Levels of anti-oxidants and pro-oxidants can vary in HDL-cholesterol, as can its effects on LDL-induced inflammation. This Review describes recent progress that might lead to new therapeutic approaches.

    • Mohamad Navab
    • Gattadahalli M Anantharamaiah
    • Alan M Fogelman
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 504-511

  • Although apolipoprotein A-I has benefits in relation to atherosclerosis, this large protein can only be administered intravenously and is difficult and expensive to manufacture. Smaller peptides that mimic apolipoprotein A-I and yield the same beneficial effects have, therefore, been sought. The advances being made in this therapeutic area are described.

    • Mohamad Navab
    • GM Anantharamaiah
    • Alan M Fogelman
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 3, P: 540-547

  • Although high levels of HDL seem to be protective against clinical events from atherosclerosis, assessing the composition and function of HDL is a more-accurate approach to determine cardiovascular risk. The authors of this Review describe the atheroprotective effects of HDL, which have been attributed to its anti-inflammatory properties and role in cholesterol efflux. The relationship between impaired HDL function and cardiovascular disease is also discussed, as well as approaches to evaluate HDL functionality.

    • Mohamad Navab
    • Srinivasa T. Reddy
    • Alan M. Fogelman
    Reviews
    Nature Reviews Cardiology
    Volume: 8, P: 222-232

  • Accelerated atherosclerosis is common in patients with chronic kidney disease (CKD). The association between CKD and atherosclerosis is in part driven by the downregulated synthesis of high-density lipoprotein (HDL) and an impairment of HDL antioxidant and anti-inflammatory activity. In this Review, Vaziri and colleagues discuss the mechanisms by which CKD adversely affects HDL level, activity and ability to mediate reverse lipid transport, and describe the mechanisms by which HDL dysregulation predisposes patients to atherosclerosis and CKD progression.

    • Nosratola D. Vaziri
    • Mohamad Navab
    • Alan M. Fogelman
    Reviews
    Nature Reviews Nephrology
    Volume: 6, P: 287-296

  • The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • Thiago S. Mosqueiro
    • M. Luisa Iruela-Arispe
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19