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T-bet is a key modulator of IL-23-driven pathogenic CD4⁺ T cell responses in the intestine

How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22.

Thomas Krausgruber
Chris Schiering
Fiona Powrie
ResearchOpen Access19 May 2016
Nature Communications

Volume: 7, P: 1-12
IL-23 stabilizes an effector T_reg cell program in the tumor microenvironment

IL-23 promotes tumor growth in preclinical cancer models and correlates with adverse clinical outcomes. Here, Becher and colleagues find that IL-23 produced by tumor-associated macrophages stabilizes T_reg cell identity, promoting immunosuppression and tumor growth.

Tobias Wertheimer
Pascale Zwicky
Burkhard Becher
ResearchOpen Access14 Feb 2024
Nature Immunology

Volume: 25, P: 512-524
Correction: Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Sylvia Heink
Nir Yogev
Thomas Korn
Amendments and Corrections22 Mar 2017
Nature Immunology

Volume: 18, P: 474
Erratum: IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ Foxp3⁻ effector T cells

Valérie Dardalhon
Amit Awasthi
Vijay K Kuchroo
Amendments and Corrections01 May 2009
Nature Immunology

Volume: 10, P: 551
Angiotensin II-induced a steeper blood pressure elevation in IL-23 receptor-deficient mice: Role of interferon-γ-producing T cells

Brandon G. Shokoples
Kevin Comeau
Ernesto L. Schiffrin
Research15 Oct 2022
Hypertension Research

Volume: 46, P: 40-49
IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

Wida Razawy
Celso H. Alves
Erik Lubberts
ResearchOpen Access13 May 2021
Scientific Reports

Volume: 11, P: 1-10
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

In a mouse model of colorectal cancer, barrier deterioration results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives IL-23-dependent tumour growth.

Sergei I. Grivennikov
Kepeng Wang
Michael Karin
Research07 Nov 2012
Nature

Volume: 491, P: 254-258
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Thomas Korn
Jayagopala Reddy
Vijay K Kuchroo
Research25 Mar 2007
Nature Medicine

Volume: 13, P: 423-431
Induction and effector functions of T_H17 cells

Estelle Bettelli
Thomas Korn
Vijay K. Kuchroo
Reviews19 Jun 2008
Nature

Volume: 453, P: 1051-1057
IL-21 initiates an alternative pathway to induce proinflammatory T_H17 cells

T_H17 cells are a recently defined subset of pro-inflammatory helper T cells that are induced by the cytokines IL-6 and transforming growth factor (TGF)-β. T_H17 can also be induced by an alternative pathway in which TGF-β cooperates with IL-21.

Thomas Korn
Estelle Bettelli
Vijay K. Kuchroo
Research20 Jun 2007
Nature

Volume: 448, P: 484-487
IL-21 and TGF-β are required for differentiation of human T_H17 cells

The T_H17 pathway is thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4⁺ T cells.

Li Yang
David E. Anderson
David A. Hafler
Research01 Jul 2008
Nature

Volume: 454, P: 350-352
Reciprocal developmental pathways for the generation of pathogenic effector T_H17 and regulatory T cells

Estelle Bettelli
Yijun Carrier
Vijay K. Kuchroo
Research30 Apr 2006
Nature

Volume: 441, P: 235-238
IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4⁺ T cells by inducing Blimp1

Autoimmune diseases are regulated by the balance between pro- and anti-inflammatory cytokines. Here, the authors show that the transcriptional regulator Blimp1 is induced in inflammatory T helper cells by the cytokines IL-27 and IL-12 to counteract pro-inflammatory IL-23 and promote resolution of tissue inflammation.

Christina Heinemann
Sylvia Heink
Thomas Korn
Research06 May 2014
Nature Communications

Volume: 5, P: 1-13
DOCK8 regulates protective immunity by controlling the function and survival of RORγt⁺ ILCs

Mutations in a scaffolding protein DOCK8 are associated with increased susceptibility to bacterial infections in patients. Here, Singh et al. show that DOCK8 regulates survival and function of a subset of innate lymphoid cells (ILC3) which are involved in the protection against enteric pathogens.

Akhilesh K. Singh
Ahmet Eken
Mohamed Oukka
Research05 Aug 2014
Nature Communications

Volume: 5, P: 1-12
IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt

Negative selection of double-positive thymocytes that express autoreactive T-cell receptors plays a crucial role in the maintenance of self-tolerance. Here, the authors provide evidence that the cytokine IL-23 produced by thymic dendritic cells is involved in the depletion of double-positive thymocytes.

Hao Li
Hui-Chen Hsu
John D. Mountz
Research08 Jul 2014
Nature Communications

Volume: 5, P: 1-13
Control of T_reg and T_H17 cell differentiation by the aryl hydrocarbon receptor

The aryl hydrocarbon receptor (AHR) is the cellular receptor for a number of environment contaminants. It is shown here to induce regulatory T cells when bound to the ligand TCCD and promote T_H17 differentiation when bound to FICZ.

Francisco J. Quintana
Alexandre S. Basso
Howard L. Weiner
Research23 Mar 2008
Nature

Volume: 453, P: 65-71
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Amit Awasthi
Yijun Carrier
Howard L Weiner
Research11 Nov 2007
Nature Immunology

Volume: 8, P: 1380-1389
T-bet represses T_H17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

Transcription factors specific for helper T cell lineages, such as T-bet, counter-regulate helper T cell development, but the details of this remain unclear. Glimcher and colleagues unravel the molecular basis of the regulation of T_H17 cells by T-bet.

Vanja Lazarevic
Xi Chen
Laurie H Glimcher
Research12 Dec 2010
Nature Immunology

Volume: 12, P: 96-104
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity

Single-nucleotide polymorphisms in the gene encoding the cytosolic viral sensor IFIH1 are linked to a variety of autoimmune diseases. Rawlings and colleagues demonstrate that one such common polymorphism results in IFIH1 with more-potent activation and can act synergistically with other genetic backgrounds to manifest autoimmune disease.

Jacquelyn A Gorman
Christian Hundhausen
David J Rawlings
Research29 May 2017
Nature Immunology

Volume: 18, P: 744-752
IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ IL-10⁺ Foxp3⁻ effector T cells

Foxp3 is required for the generation and function of regulatory T cells. Kuchroo and colleagues find that interleukin 4 blocks the generation of these cells but promotes T helper cells that produce interleukins 9 and 10.

Valérie Dardalhon
Amit Awasthi
Vijay K Kuchroo
Research09 Nov 2008
Nature Immunology

Volume: 9, P: 1347-1355
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

Antibody production is the main effector function of B cells. Rawlings and colleagues show that Trypanosome cruzi induces rapid IL-17 production by B cells that is required for parasite control.

Daniela A Bermejo
Shaun W Jackson
David J Rawlings
Research07 Apr 2013
Nature Immunology

Volume: 14, P: 514-522
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Korn and colleagues report that Sirpα⁺ dendritic cells trans-present the cytokine IL-6 to T cells through a process that requires its receptor IL-6Rα bound to dendritic cells and that trans-presentation is needed to generate pathogenic cells of the T_H17 subset of helper T cells in vivo.

Sylvia Heink
Nir Yogev
Thomas Korn
Research28 Nov 2016
Nature Immunology

Volume: 18, P: 74-85
T_H-17 cells in the circle of immunity and autoimmunity

Estelle Bettelli
Mohamed Oukka
Vijay K Kuchroo
Reviews01 Apr 2007
Nature Immunology

Volume: 8, P: 345-350
S1P₁ deletion differentially affects TH17 and Regulatory T cells

Ahmet Eken
Rebekka Duhen
Mohamed Oukka
ResearchOpen Access10 Oct 2017
Scientific Reports

Volume: 7, P: 1-13

Search

T-bet is a key modulator of IL-23-driven pathogenic CD4⁺ T cell responses in the intestine

IL-23 stabilizes an effector T_reg cell program in the tumor microenvironment

Correction: Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Erratum: IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ Foxp3⁻ effector T cells

Angiotensin II-induced a steeper blood pressure elevation in IL-23 receptor-deficient mice: Role of interferon-γ-producing T cells

IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Induction and effector functions of T_H17 cells

IL-21 initiates an alternative pathway to induce proinflammatory T_H17 cells

IL-21 and TGF-β are required for differentiation of human T_H17 cells

Reciprocal developmental pathways for the generation of pathogenic effector T_H17 and regulatory T cells

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4⁺ T cells by inducing Blimp1

DOCK8 regulates protective immunity by controlling the function and survival of RORγt⁺ ILCs

IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt

Control of T_reg and T_H17 cell differentiation by the aryl hydrocarbon receptor

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

T-bet represses T_H17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity

IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ IL-10⁺ Foxp3⁻ effector T cells

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

T_H-17 cells in the circle of immunity and autoimmunity

S1P₁ deletion differentially affects TH17 and Regulatory T cells

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