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Showing 1–4 of 4 results
Advanced filters: Author: Mohammad HamediRad Clear advanced filters

  • Genome-scale engineering is generally limited to single methods of alteration such as overexpression, repression or deletion. Here the authors present a tri-functional CRISPR system that can engineer complex synergistic interactions in a genome-wide manner.

    • Jiazhang Lian
    • Carl Schultz
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Existing efforts have been focused on one of the elements in the automation of the design, build, test, and learn (DBTL) cycle for biosystems design. Here, the authors integrate a robotic system with machine learning algorithms to fully automate the DBTL cycle and apply it in optimizing the lycopene biosynthetic pathway.

    • Mohammad HamediRad
    • Ran Chao
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Metaboli engineering through gene overexpression, knock-down and knock-out is often carried out sequentially in a high labor, low-throughput manner. Here, the authors use CRISPR-mediated gene activation, interference and deletion to rapidly rewire S. cerevisiae metabolism in a single step.

    • Jiazhang Lian
    • Mohammad HamediRad
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9