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Selective positive allosteric modulation of β₂AR using antibody fragments targeting the third intracellular loop

G protein-coupled receptor (GPCR) therapeutics primarily target structured and sequence conserved domains limiting target selectivity. Here, authors demonstrate the mechanism for selective modulation of a GPCR through disordered regions.

Edgardo J. Sánchez Rivas
Fredrik Sadler
Sivaraj Sivaramakrishnan
ResearchOpen Access06 May 2026
Nature Communications

P: 1-15

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Selective positive allosteric modulation of β2AR using antibody fragments targeting the third intracellular loop

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Selective positive allosteric modulation of β₂AR using antibody fragments targeting the third intracellular loop