Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Mohsan Saeed Clear advanced filters

  • A stampede of recent clinical studies suggests that we are on the cusp of developing well-tolerated, orally delivered drugs that can effectively eradicate hepatitis C virus from most, if not all, infected individuals.

    • Charles M. Rice
    • Mohsan Saeed
    News & Views
    Nature
    Volume: 510, P: 43-44

  • To model hepatocyte function accurately in vitro, it is necessary to generate and maintain a polarized epithelium. Here, the authors describe a protocol to generate polarized human pluripotent stem cell-derived hepatocyte-like cells (HLCs) to model enteric virus production and drug secretion in vitro.

    • Viet Loan Dao Thi
    • Xianfang Wu
    • Charles M. Rice
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.

    • Monir Ejemel
    • Qi Li
    • Yang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Comparisons of a chimeric recombinant version of SARS-CoV-2, the ancestral SARS-CoV-2 strain and an Omicron isolate show that the attenuated virulence of Omicron is caused by mutations in both the spike protein and nsp6.

    • Da-Yuan Chen
    • Chue Vin Chin
    • Mohsan Saeed
    Research
    Nature
    Volume: 615, P: 143-150

  • Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.

    • Christopher L. Robinson
    • Angie C. N. Chong
    • Shuibing Chen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • After mosquito bite, the malaria parasite first infects the liver, where it is thought to be undetected by the host immune system as it develops into the blood-stage pathogen. Maria Mota and her colleagues now report that Plasmodium RNA is detected by hepatocytes, triggering an interferon response that controls the parasite burden in the liver and blood of infected mice.

    • Peter Liehl
    • Vanessa Zuzarte-Luís
    • Maria M Mota
    Research
    Nature Medicine
    Volume: 20, P: 47-53

  • Here, the authors identify lymphocyte antigen 6E (LY6E) as a coronavirus (CoV) restriction factor that prevents infection of B cells and dendritic cells. LY6E inhibits both human and mouse CoV entry into cells by interfering with viral spike protein-mediated membrane fusion. It facilitates an antiviral immune response that prevents liver disease and reduces death in the mouse model of MHV-A59 CoV infection.

    • Stephanie Pfaender
    • Katrina B. Mar
    • Volker Thiel
    Research
    Nature Microbiology
    Volume: 5, P: 1330-1339

  • Hepatitis C virus cannot replicate in cell culture unless it possesses adaptive mutations; here, expression of cellular factor SEC14L2 is shown to allow replication of diverse hepatitis C virus genotypes in several hepatoma cell lines by enhancing vitamin E-mediated protection against lipid peroxidation.

    • Mohsan Saeed
    • Ursula Andreo
    • Charles M. Rice
    Research
    Nature
    Volume: 524, P: 471-475