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Showing 1–4 of 4 results
Advanced filters: Author: Mohsin Badat Clear advanced filters

  • Micro Capture-C allows physical contacts to be determined at base-pair resolution, revealing that transcription factors have an important role in the maintenance of the contacts between enhancers and promoters.

    • Peng Hua
    • Mohsin Badat
    • James O. J. Davies
    Research
    Nature
    Volume: 595, P: 125-129

  • Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may explain the ancient synteny of α -globin with Nprl3.

    • Alexandra E. Preston
    • Joe N. Frost
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The authors demonstrate efficient and direct correction of the DNA mutation causing Haemoglobin E β-thalassaemia with CRISPR Cas9 base editors. The work includes profiling of off-target effects using deep neural networks.

    • Mohsin Badat
    • Ayesha Ejaz
    • James O. J. Davies
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7