Alborz Mazloomian et al. use small molecule inhibitors to disrupt EIF4A3’s ATPase and helicase function which affects alternative splicing and nonsense mediated decay of transcripts. They define a genome-wide pattern of motifs of RNA-binding proteins associated with EIF4A3 and find that stress granules are downregulated upon EIF4A3 inhibition.
- Alborz Mazloomian
- Shinsuke Araki
- Samuel Aparicio
