Mona Tonn et al. propose a stochastic model to elucidate the mechanisms by which non-genetic heterogeneity arises in metabolic reactions. They find that even unimodal enzyme expression fluctuations can lead to highly heterogeneous metabolite profiles with two or more metabolically distinct subpopulations of cells.
- Mona K. Tonn
- Philipp Thomas
- Diego A. Oyarzún
