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Showing 1–7 of 7 results
Advanced filters: Author: Monica Giomo Clear advanced filters

  • Hydrogel force sensors directly bioprinted into embryonic tissues quantify the forces driving tissue remodelling and reveal the existence of mechanisms that counteract tissue morphogenesis.

    • Eirini Maniou
    • Silvia Todros
    • Nicola Elvassore
    ResearchOpen Access
    Nature Materials
    Volume: 23, P: 1575-1581

  • The roles of CoQ10 and producing enzymes in cancer have not been well explored. Here, the authors identify that the CoQ10-biosynthetic enzyme UBIAD1 is a tumor suppressor in breast cancer. CoQ10 induced alterations in plasma membrane mechanical properties lead to increased cellular stiffness and impaired tumorigenic signaling, as well as enhanced sensitivity to ferroptosis.

    • Giovanni Tosi
    • Alessandro Paoli
    • Massimo M. Santoro
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Organ-like 3D cultures are advanced model system for biology and medicine limited by their uncontrolled cell self-assembly. Here, the authors develop a hydrogel-in-hydrogel bioprinting approach to dynamically control the growth landscape of a broad range of living 3D cell cultures.

    • Anna Urciuolo
    • Giovanni Giuseppe Giobbe
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Romani et al. report that cells on soft extracellular matrix have increased mitochondrial fission, with subsequent production of mitochondrial reactive oxygen species and NRF2, which may increase resistance to reactive oxygen species-dependent chemotherapy drugs in breast cancer cells in vitro and in mouse lungs.

    • Patrizia Romani
    • Nunzia Nirchio
    • Sirio Dupont
    Research
    Nature Cell Biology
    Volume: 24, P: 168-180

  • Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.

    • Giovanni Giuseppe Giobbe
    • Claire Crowley
    • Paolo De Coppi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Three-dimensional cell-laden photosensitive polymer hydrogels can be bioprinted in tissues of live animals, by bio-orthogonal two-photon cycloaddition and crosslinking of the polymers.

    • Anna Urciuolo
    • Ilaria Poli
    • Nicola Elvassore
    Research
    Nature Biomedical Engineering
    Volume: 4, P: 901-915

  • We developed tissue-engineered neuromuscular organoids by combining decellularized skeletal muscle and hiPSCs. The provided ECM scaffolds improved cell maturation, enabling the study of (dys)functional skeletal muscle.

    • Beatrice Auletta
    • Pietro Chiolerio
    • Anna Urciuolo
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-17