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Advanced filters: Author: Monika Miś Clear advanced filters

  • How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases in prostate cancer models.

    • Kristin M. Zimmerman Savill
    • Brian B. Lee
    • Kui Lin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17