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Showing 1–6 of 6 results
Advanced filters: Author: Moran Shalev-Benami Clear advanced filters

  • The thromboxane A2 receptor (TP) is an important mediator of cardiovascular homeostasis. Here, authors report two structures of active TP-Gq bound to U46619 and I-BOP, revealing a molecular mechanism of TP activation and providing mechanistic insights into disease-associated TP mutations.

    • Pawel Krawinski
    • Donna Matzov
    • Moran Shalev-Benami
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • A method termed ac4C-seq is introduced for the transcriptome-wide mapping of the RNA modification N4-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.

    • Aldema Sas-Chen
    • Justin M. Thomas
    • Schraga Schwartz
    Research
    Nature
    Volume: 583, P: 638-643

  • Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket that mediate PAR deleterious effects on the parasite.

    • Moran Shalev-Benami
    • Yan Zhang
    • Georgios Skiniotis
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Bitter taste receptors (TAS2Rs) are a subfamily of G-protein coupled receptors (GPCRs). Here, the authors report a cryo-EM structure of the human TAS2R14 in complex with its signaling partner gustducin, and bound to an anti-inflammatory drug flufenamic acid (FFA).

    • Lior Peri
    • Donna Matzov
    • Moran Shalev-Benami
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Cryo-electron microscopy structures of GPR56 and latrophilin 3 show how the released tethered agonist peptide interacts with the transmembrane domain, suggesting a model for the activation mechanism of adhesion G-protein-coupled receptors.

    • Ximena Barros-Álvarez
    • Robert M. Nwokonko
    • Georgios Skiniotis
    Research
    Nature
    Volume: 604, P: 757-762