Activity is thought to help shape connectivity within neural circuits, with differences often leading to the elimination of less active connections. In order to imbalance neurotransmission from different sets of inputs in vivo, a subpopulation of bipolar cells was inactivated during development. The results reveal an unexpected and remarkably selective role for activity in circuit development, regulating synapse formation but not elimination.
- Daniel Kerschensteiner
- Josh L. Morgan
- Rachel O. L. Wong
