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Advanced filters: Author: Morgane Decollogny Clear advanced filters

  • Histone H2AX has a known role in DNA damage repair but interestingly, its loss is associated with resistance to poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-deficient tumours. Here, the authors identify a role of γH2AX in the degradation of replication forks and demonstrate that H2AX loss drives PARP inhibitor resistance via increased stressed fork stability in BRCA-deficient tumours.

    • Diego Dibitetto
    • Martin Liptay
    • Sven Rottenberg
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14