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High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing

Advancements in spatial transcriptomics technologies have enabled the analysis of gene expression at cellular resolution in situ. The authors applied direct RNA hybridization-based in situ sequencing (dRNA HybISS) and developed a computational tool, CellScopes, to study gene expression in mouse kidneys, identifying cellular changes and interactions during injury and repair.

Haojia Wu
Eryn E. Dixon
Benjamin D. Humphreys
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-16
High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis

The integration of single-cell and spatial data can provide a more comprehensive picture of the network of cells within the tumour microenvironment. Here the authors use a combination of single-cell and spatial technologies including 10x Xenium to characterise serial formalin-fixed, paraffin-embedded human breast cancer sections.

Amanda Janesick
Robert Shelansky
Sarah E. B. Taylor
ResearchOpen Access19 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

Large-scale sequencing of coding exons of MRAP2 in 9,418 adults and adolescents identifies loss-of-function mutations that are associated with monogenic obesity, hypertension and hyperglycemia.

Morgane Baron
Julie Maillet
Amélie Bonnefond
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1733-1738

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High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing

High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

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