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Showing 1–4 of 4 results
Advanced filters: Author: Moritz Ochmann Clear advanced filters

  • H3K36me3 is a marker of actively and recently transcribed genes. Here, the authors describe a 3-step mechanism of transcription-coupled H3K36me3 deposition by the mammalian methyltransferase SETD2, via the elongation factor SPT6.

    • James L. Walshe
    • Moritz Ochmann
    • Patrick Cramer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Although IWS1 has been implicated in transcription-coupled processes, its direct role in RNA polymerase II function remained undefined. Here, the authors demonstrate that IWS1 enhances Pol II elongation velocity by acting as a structural scaffold and promoting co-transcriptional H3K36me3 deposition.

    • Aiturgan Zheenbekova
    • James L. Walshe
    • Kristina Žumer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.

    • Isaac Fianu
    • Moritz Ochmann
    • Patrick Cramer
    ResearchOpen Access
    Nature
    Volume: 629, P: 219-227

  • Structural and functional analyses of RNA polymerase II−nucleosome complexes reveal how the chromatin remodeler Chd1 and the histone chaperone FACT mediate Pol II transcription through a nucleosome.

    • Lucas Farnung
    • Moritz Ochmann
    • Patrick Cramer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 28, P: 382-387