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Showing 1–3 of 3 results

Advanced filters: Author: Moritz Weigl Clear advanced filters

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene amplifications in human cancers.

Davide Pradella
Minsi Zhang
Andrea Ventura
ResearchOpen Access18 Dec 2024
Nature

Volume: 637, P: 955-964
Senolytics improve physical function and increase lifespan in old age

Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.

Ming Xu
Tamar Pirtskhalava
James L. Kirkland
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1246-1256
SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema

Eleni Priglinger
Karin Strohmeier
Susanne Wolbank
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-12