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Showing 1–4 of 4 results
Advanced filters: Author: Moriz Mayer Clear advanced filters

  • Citizen science taps the efforts of non-experts. Here, authors describe Drugit, an extension of the crowdsourcing game Foldit, and its use in designing a non-peptide binder of Von Hippel Lindau E3 ligase for use with proteolysis targeting chimeras.

    • Thomas Scott
    • Christian Alan Paul Smethurst
    • Rocco Moretti
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally bioavailable and selective degrader of SMARCA2.

    • Christiane Kofink
    • Nicole Trainor
    • William Farnaby
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A chemical probe BI-9321 for the PWWP1 domain of NSD3 and its inactive analog were identified. BI-9321 binds to the methyl-lysine binding site, reduces the association of NSD3 with chromatin and inhibits proliferation of acute myeloid leukemia cells.

    • Jark Böttcher
    • David Dilworth
    • Darryl B. McConnell
    Research
    Nature Chemical Biology
    Volume: 15, P: 822-829

  • High-resolution 3D structural data are essential for drug discovery, yet X-ray crystallography has limitations in guiding medicinal chemistry. Here, the authors discuss the use of solution-state NMR spectroscopy with selective side-chain labeling and advanced computational workflows to produce accurate protein-ligand ensembles, enhancing structural insights for medicinal chemists and enabling high-throughput applications.

    • Gerald Platzer
    • Moriz Mayer
    • Robert Konrat
    ReviewsOpen Access
    Communications Chemistry
    Volume: 8, P: 1-8