Nature Search

Isolation of the human placenta receptor for epidermal growth factor-urogastrone

R. ALAN HOCK
EBBA NEXØ
MORLEY D. HOLLENBERG
Research01 Feb 1979
Nature

Volume: 277, P: 403-405
Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Helvira Melo
Lilian Basso
Christophe Altier
ResearchOpen Access19 Oct 2018
Scientific Reports

Volume: 8, P: 1-9
Active thrombin produced by the intestinal epithelium controls mucosal biofilms

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

Jean-Paul Motta
Alexandre Denadai-Souza
Nathalie Vergnolle
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-12
High Expression of Pulmonary Proteinase-activated Receptor 2 in Acute and Chronic Lung Injury in Preterm Infants

Katariina Cederqvist
Caj Haglund
Sture Andersson
Research01 Jun 2005
Pediatric Research

Volume: 57, P: 831-836
Targeting proteinase-activated receptors: therapeutic potential and challenges

Here, the authors highlight the role of proteinase-activated receptors in physiology and in conditions such as cancer and cardiovascular disorders. They also review possible strategies for developing proteinase-activated receptor antagonists and the challenges associated with this goal.

Rithwik Ramachandran
Farshid Noorbakhsh
Morley D. Hollenberg
Reviews03 Jan 2012
Nature Reviews Drug Discovery

Volume: 11, P: 69-86
Proteolytic dysfunction in bovine digital dermatitis caused by Treponema spp. and the therapeutic use of non-antimicrobial matrix metalloproteinase inhibitors

CMC2.24, a non-antibiotic metalloprotease inhibitor, alleviates digital dermatitis lesions in cattle caused by Treponema spp., preventing chronicity and promoting healing by downregulating keratinization and inflammatory pathways.

Priyoshi Lahiri
Daniel Young
Eduardo R. Cobo
ResearchOpen Access29 Oct 2025
Communications Biology

Volume: 8, P: 1-16
Proteinases and their receptors in inflammatory arthritis: an overview

Proteinases orchestrate many processes in inflammatory arthritis, but their ability to signal via proteolytically activated receptors is often overlooked. This Review provides an overview of proteinases and their receptors in inflammatory arthritis, alongside suggestions for therapeutically targeting these pathways.

Katerina Oikonomopoulou
Eleftherios P. Diamandis
Vinod Chandran
Reviews08 Feb 2018
Nature Reviews Rheumatology

Volume: 14, P: 170-180
Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

The G protein–coupled receptor F2rl1 translocates from the plasma membrane to the nucleus of retinal ganglion neurons to control Vegfa expression and retinal angiogenesis.

Jean-Sébastien Joyal
Satra Nim
Sylvain Chemtob
Research14 Sept 2014
Nature Medicine

Volume: 20, P: 1165-1173
Proteinase-activated receptors in the nervous system

Farshid Noorbakhsh
Nathalie Vergnolle
Christopher Power
Reviews01 Dec 2003
Nature Reviews Neuroscience

Volume: 4, P: 981-990
The RGS-RhoGEFs control the amplitude of YAP1 activation by serum

Brandon S. Lane
Brigitte Heller
Clark D. Wells
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
A KLK4 proteinase substrate capture approach to antagonize PAR1

Eitan Rabinovitch
Koishiro Mihara
Niv Papo
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin

Vatsal Sachan
Robert Lodge
Nabil G. Seidah
Research25 Jan 2019
Cell Death & Differentiation

Volume: 26, P: 1942-1954
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Alexandre Denadai-Souza
Chrystelle Bonnart
Céline Deraison
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-9

Search

Isolation of the human placenta receptor for epidermal growth factor-urogastrone

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

High Expression of Pulmonary Proteinase-activated Receptor 2 in Acute and Chronic Lung Injury in Preterm Infants

Targeting proteinase-activated receptors: therapeutic potential and challenges

Proteolytic dysfunction in bovine digital dermatitis caused by Treponema spp. and the therapeutic use of non-antimicrobial matrix metalloproteinase inhibitors

Proteinases and their receptors in inflammatory arthritis: an overview

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

Proteinase-activated receptors in the nervous system

The RGS-RhoGEFs control the amplitude of YAP1 activation by serum

A KLK4 proteinase substrate capture approach to antagonize PAR1

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

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