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Showing 1–4 of 4 results
Advanced filters: Author: Moshe Goldsmith Clear advanced filters

  • Random and targeted mutagenesis of serum paraoxonase, coupled with the development of a screen that allows detection of enzymatic activity against the toxic isomer of cyclosarin, yielded a mutant enzyme capable of protecting mice from a lethal dose of this dangerous nerve agent.

    • Rinkoo D Gupta
    • Moshe Goldsmith
    • Dan S Tawfik
    Research
    Nature Chemical Biology
    Volume: 7, P: 120-125

  • Organisms regulate biogenic crystal properties for various functions. Here the authors reveal the genetic and biochemical control of crystal morphogenesis in zebrafish iridophores, showing that the chemical composition, influenced by enzyme expression, determines crystal morphology and functionality.

    • Rachael Deis
    • Tali Lerer-Goldshtein
    • Dvir Gur
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 383-392

  • Metals serve as unique structural and functional elements in biology, providing a wealth of reactivities not available in a wholly proteinogenic active site. The computational redesign and directed evolution of zinc enzymes to create a phosphotriesterase provides insights into how these elements can be utilized in the development of new functions.

    • Sagar D Khare
    • Yakov Kipnis
    • David Baker
    Research
    Nature Chemical Biology
    Volume: 8, P: 294-300